Rheumatology Research

The Rheumatology Division is involved in both basic and clinical research. As part of the Research Institute at CHOC, the Division is involved in the understanding of chronic inflammation in juvenile rheumatoid arthritis (JRA) and DNA repair in systemic lupus erythematosus (SLE). We have cloned a gene expressed in the synovial tissue from inflamed joints from patients with JRA and are exploring its role in the pathogenesis of inflammation.

This work is ongoing and has resulted in two abstracts at the American College of Rheumatology meetings and two papers in peer-reviewed journals. Our laboratory is also studying DNA repair in SLE and scleroderma. This is a fascinating area and may lead to a better understanding of disease pathogenesis. Our preliminary work has been presented in one abstract and one paper. We have also been involved in clinical trials for new medications in the treatment of JRA and SLE in children. We have participated in five clinical trials and collected data for future drug marketing. Some of these medications are revolutionizing the care of children with JRA.

For more information, please contact our Administrative Office at (714) 532-8617.